Jundishapur Journal of Chronic Disease Care

Published by: Kowsar

Association of General Obesity With Hyperhomocysteinemia in Patients With Migraine

Omid Sadeghi 1 , Gholamreza Askari 1 , Zahra Maghsoudi 1 , Morteza Nasiri 2 , * , Fariborz Khorvash 3 and Reza Ghiasvand 1
Authors Information
1 Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, IR Iran
2 Student Research Committee, Nursing and Midwifery School, Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3 Neurology Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran
Article information
  • Jundishapur Journal of Chronic Disease Care: January 01, 2015, 4 (1); e26596
  • Published Online: January 19, 2015
  • Article Type: Research Article
  • Received: July 4, 2014
  • Revised: September 21, 2014
  • Accepted: November 5, 2014
  • DOI: 10.5812/jjcdc.26596

To Cite: Sadeghi O, Askari G, Maghsoudi Z, Nasiri M, Khorvash F, et al. Association of General Obesity With Hyperhomocysteinemia in Patients With Migraine, Jundishapur J Chronic Dis Care. 2015 ; 4(1):e26596. doi: 10.5812/jjcdc.26596.

Copyright © 2015, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Xi B, Liang Y, He T, Reilly KH, Hu Y, Wang Q, et al. Secular trends in the prevalence of general and abdominal obesity among Chinese adults, 1993-2009. Obes Rev. 2012; 13(3): 287-96[DOI][PubMed]
  • 2. Azadbakht L, Esmaillzadeh A. Dietary and non-dietary determinants of central adiposity among Tehrani women. Public Health Nutr. 2008; 11(5): 528-34[DOI][PubMed]
  • 3. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA. 2012; 307(5): 491-7[DOI][PubMed]
  • 4. Gutierrez-Fisac JL, Guallar-Castillon P, Leon-Munoz LM, Graciani A, Banegas JR, Rodriguez-Artalejo F. Prevalence of general and abdominal obesity in the adult population of Spain, 2008-2010: the ENRICA study. Obes Rev. 2012; 13(4): 388-92[DOI][PubMed]
  • 5. Khorvash F, Mottaghi T, Askari G, Maracy MR, Ghiasvand R, Maghsoudi Z, et al. The association between serum vitamin d levels with general and abdominal obesity among patients with migraine. Int J Prev Med. 2013; 4-7[PubMed]
  • 6. Da Costa LA, Arora P, Garcia-Bailo B, Karmali M, El-Sohemy A, Badawi A. The association between obesity, cardiometabolic disease biomarkers, and innate immunity-related inflammation in Canadian adults. Diabetes Metab Syndr Obes. 2012; 5: 347-55[DOI][PubMed]
  • 7. Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature. 2006; 444(7121): 875-80[DOI][PubMed]
  • 8. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006; 444(7121): 860-7[DOI][PubMed]
  • 9. Westphal SA. Obesity, Abdominal Obesity, and Insulin Resistance. Clinical Cornerstone. 2008; 9(1): 23-31[DOI]
  • 10. Huemer M, Vonblon K, Fodinger M, Krumpholz R, Hubmann M, Ulmer H, et al. Total homocysteine, folate, and cobalamin, and their relation to genetic polymorphisms, lifestyle and body mass index in healthy children and adolescents. Pediatr Res. 2006; 60(6): 764-9[DOI][PubMed]
  • 11. Papandreou D, Rousso I, Makedou A, Arvanitidou M, Mavromichalis I. Association of blood pressure, obesity and serum homocysteine levels in healthy children. Acta Paediatr. 2007; 96(12): 1819-23[DOI][PubMed]
  • 12. Konukoglu D, Serin O, Ercan M, Turhan MS. Plasma homocysteine levels in obese and non-obese subjects with or without hypertension; its relationship with oxidative stress and copper. Clin Biochem. 2003; 36(5): 405-8[PubMed]
  • 13. Ercan M, Konukoglu D. Role of plasma viscosity and plasma homocysteine level on hyperinsulinemic obese female subjects. Clin Hemorheol Microcirc. 2008; 38(4): 227-34[PubMed]
  • 14. Bautista LE, Arenas IA, Penuela A, Martinez LX. Total plasma homocysteine level and risk of cardiovascular disease: a meta-analysis of prospective cohort studies. J Clin Epidemiol. 2002; 55(9): 882-7[PubMed]
  • 15. Casas JP, Bautista LE, Smeeth L, Sharma P, Hingorani AD. Homocysteine and stroke: evidence on a causal link from mendelian randomisation. Lancet. 2005; 365(9455): 224-32[DOI][PubMed]
  • 16. Micle O, Muresan M, Antal L, Bodog F, Bodog A. The influence of homocysteine and oxidative stress on pregnancy outcome. J Med Life. 2012; 5(1): 68-73[PubMed]
  • 17. Yu S, Liu R, Yang X, Zhao G, Qiao X, Feng J, et al. Body mass index and migraine: a survey of the Chinese adult population. J Headache Pain. 2012; 13(7): 531-6[DOI][PubMed]
  • 18. Moschiano F, D'Amico D, Usai S, Grazzi L, Di Stefano M, Ciusani E, et al. Homocysteine plasma levels in patients with migraine with aura. Neurol Sci. 2008; 29 Suppl 1-5[DOI][PubMed]
  • 19. Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009; 19(6): 422-8[DOI][PubMed]
  • 20. Menon S, Lea RA, Roy B, Hanna M, Wee S, Haupt LM, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012; 22(10): 741-9[DOI][PubMed]
  • 21. Rhee EJ, Hwang ST, Lee WY, Yoon JH, Kim BJ, Kim BS, et al. Relationship between metabolic syndrome categorized by newly recommended by International Diabetes Federation criteria with plasma homocysteine concentration. Endocr J. 2007; 54(6): 995-1002[PubMed]
  • 22. Nakazato M, Maeda T, Takamura N, Wada M, Yamasaki H, Johnston KE, et al. Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults. Eur J Nutr. 2011; 50(7): 581-5[DOI][PubMed]
  • 23. Elshorbagy AK, Nurk E, Gjesdal CG, Tell GS, Ueland PM, Nygard O, et al. Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism? Am J Clin Nutr. 2008; 88(3): 738-46[PubMed]
  • 24. Headache Classification Subcommittee of the International Headache, Society . Cephalalgia 24 Suppl 1
  • 25. Park SB, Georgiades A. Changes in body composition predict homocysteine changes and hyperhomocysteinemia in Korea. J Korean Med Sci. 2013; 28(7): 1015-20[DOI][PubMed]
  • 26. Sanlier N, Yabanci N. Relationship between body mass index, lipids and homocysteine levels in university students. J Pak Med Assoc. 2007; 57(10): 491-5[PubMed]
  • 27. Battezzati A, Bertoli S, San Romerio A, Testolin G. Body composition: an important determinant of homocysteine and methionine concentrations in healthy individuals. Nutr Metab Cardiovasc Dis. 2007; 17(7): 525-34[DOI][PubMed]
  • 28. Gallistl S, Sudi KM, Erwa W, Aigner R, Borkenstein M. Determinants of homocysteine during weight reduction in obese children and adolescents. Metabolism. 2001; 50(10): 1220-3[DOI][PubMed]
  • 29. Mojtabai R. Body mass index and serum folate in childbearing age women. Eur J Epidemiol. 2004; 19(11): 1029-36[PubMed]
  • 30. McCarty MF. Supplemental creatine may decrease serum homocysteine and abolish the homocysteine 'gender gap' by suppressing endogenous creatine synthesis. Med Hypotheses. 2001; 56(1): 5-7[DOI][PubMed]
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