Effect of Vitamin E Vaginal Suppository on Atrophic Vaginitis Among Postmenopausal Women

AUTHORS

Sara Ziagham 1 , * , Zahra Abbaspoor 2 , Sara Safyari 3 , Parasto Rad 4

1 Department of Midwifery, Shushtar Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran

2 Department of Midwifery, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran

3 Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran

4 Department of Midwifery, School of Nursing and Midwifery, Yasuj University of Medical Sciences, Yasuj, IR Iran

How to Cite: Ziagham S, Abbaspoor Z, Safyari S, Rad P. Effect of Vitamin E Vaginal Suppository on Atrophic Vaginitis Among Postmenopausal Women, Jundishapur J Chronic Dis Care. Online ahead of Print ; 2(4):32255.

ARTICLE INFORMATION

Jundishapur Journal of Chronic Disease Care: 2 (4); 32255
Published Online: November 15, 2013
Article Type: Research Article
Received: December 16, 2012
Accepted: March 15, 2013

Crossmark

CHEKING

READ FULL TEXT
Abstract

Introduction: Urogenital atrophy is a common problem after menopause, and results from declining estradiol levels and may causes symptoms that can significantly affect quality of life. The aim of this study was to determine the effect of the vaginal suppository of vitamin E in the treatment of atrophic vaginities.

Materials and Methods: This randomized, double-blind controlled trail study was carried out on 42 postmenopausal women with of vaginal atrophy symptoms. The women were randomized in two groups to take vaginal suppository containing 1 mg vitamin E (n = 20) or placebo (n = 22) for 8 weeks. The symptoms of vaginal atrophy, vaginal pH and maturation value were measured and compared in both groups before and after treatment. Data were analyzed using t-test and Chi square in SPSS version 16.

Results: The results showed that the symptoms of atrophy were relieved significantly in recipient vitamin E group (P < 0.001). A significant decrease in vaginal pH was detected in recipient vitamin E group compared to placebo group (P < 0.001). In addition, the mean maturation index was significantly higher in vitamin E group compared with placebo group (P < 0.002).

Conclusions: The results showed that vitamin E relieves symptoms of vaginal atrophy. Therefore, the use of vitamin E vaginal suppositories is recommended for the women with vaginal atrophy who do not want or cannot receive a topical estrogen treatment.

Keywords

Menopause Vaginal Atrophy Maturation Index Vitamin E Vaginal pH

© 2013, Jundishapur Journal of Chronic Disease Care. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF

COMMENTS

LEAVE A COMMENT HERE: