Migraine and Risk of Stroke: Review of Current Evidence

AUTHORS

Omid Sadeghi 1 , Gholamreza Askari 1 , Zahra Maghsoudi 1 , Morteza Nasiri 2 , * , Fariborz Khorvash 3

1 Department of Community Nutrition, Food Safety Research Center, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, IR Iran

2 Department of Nursing, Chronic Disease Care Research Center, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran

3 Neurology Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran

How to Cite: Sadeghi O, Askari G, Maghsoudi Z, Nasiri M, Khorvash F. Migraine and Risk of Stroke: Review of Current Evidence, Jundishapur J Chronic Dis Care. 2014 ; 3(3):e93799. doi: 10.17795/jjcdc-21707.

ARTICLE INFORMATION

Jundishapur Journal of Chronic Disease Care: 3 (3); e93799
Published Online: July 26, 2014
Article Type: Review Article
Received: May 15, 2019
Accepted: May 16, 2014
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Abstract

Context: Migraine is a kind of primary headache that affects 10% to 20% of people worldwide. Recent studies have shown that migraines can be involved in strokes incidences, especially ischemic strokes.Hence, the current study aimed to review evidence in relation to migraine and risk of stroke.

Evidence Acquisition: A literature search was done for related articles dated between 1993 and 2013 on PubMed, Science Direct, Embase, Web of Science and Scopus for both English and non-English language articles by entering “migraine”, “migraine with aura”, “headache” and “ischemic and hemorrhagic stroke” as keywords.

Results: In most evaluated studies, there was a positive association between migraine with aura (MA) and strokes incidences, especially ischemic strokes. Moreover, patients with high frequency of migraine attacks had greater odds of having a stroke compared with those who had low frequency of migraine attacks. Also, the association between migraine and stroke was more significant in subjects under 45 years old. Some migraine symptoms such as vomiting and nausea had a protective role in the development of ischemic strokes.

Conclusions: Migraine, especially MA, is a risk factor for incidences of strokes, especially ischemic strokes. However, due to conflicting results on the association between different types of migraine and stroke, more studies are needed in this field.

Keywords

Migraine Disorders Headache Stroke

© 2014, Jundishapur Journal of Chronic Disease Care. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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